Publication Title The P1A2 Genetic Polymorphism of Platelet Glycoprotein IIIa enhances the Risk of Neurocognitive Decline after Cardiopulmonary Bypass  Date Published 2001  Journal Published. Ann Thorac Surg, Vol. 71, 663-666  Authors Mathew J, Rinder CS, Rinder HM, Howe JG, Crouch JJ, Newman M,  Abstract Neurocognitive decline, often produced by atherosclerotic plaque embolization, remains a frequent complication of cardiopulmonary bypass. Plaque fragments may initiate local thrombosis, which, in turn, aggravates the embolic insult. Prothrombotic genetic factors may exacerbate this process. We investigated whether the P1A2 polymorphism of platelet GP111a, a prothrombotic risk factor in other cardiovascular settings, is associated with early neurocognitive decline after cardiopulmonary bypass.